Being respected and appreciated by significant others is one of the most fundamental human needs. Consequently, people go to great pain to gain acceptance and approval. Recent research in the domain of occupational health psychology shows that many stressful experiences are linked to being offended – for instance, by being offended or ridiculed, by social exclusion, by social conflict, by illegitimate tasks. Such experiences of being treated in an unfair manner constitute an “Offence to Self”, and this may have quite far reaching consequences in terms of health and well-being. Conversely, being appreciated is one of the most important factors that increases motivation and satisfaction as well as health and well-being. The presentation below covers examples from recent research and draws conclusions concerning the many ways in which appreciation and respect (or lack thereof) can be communicated and how this knowledge can be useful for prevention in the field of health and well-being.